Efek ekstrak umbi ubi jalar ungu (Ipomoea batatas) terhadap peningkatan ekspresi ABCA1 pada tikus model dislipidemia
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- DOI: https://doi.org/10.15562/ism.v14i2.899 |
- Published: 2023-08-21
Open Access & Peer Reviewed
Multidisciplinary Journal of Science and
Medical Research
Multidisciplinary Journal of Science and
Medical Research
Abstract
Background: Maintaining the homeostasis of body fat levels is an important thing. ABCA1 is an important protein in cholesterol efflux function, which can maintain lipid profile homeostasis. Purple sweet potato (potato ipomoea batatas) is a Convolvulaceae plant with various biological functions, one of which is anthocyanin content known to prevent hyperlipidemia through ABCA1 synthesis. This study aims to examine the effect of purple sweet potato tuber extract on increasing levels of ABCA1.
Methods: Post-test-only study design with a control group using 50 male Wistar rats divided into 5 groups (n = 10). The negative treatment group (P0) was given standard feed, while the positive group (P4), treatment 1 (P1), treatment 2 (P2) and treatment 3 (P3) were given a hyperlipidemic diet for 8 weeks. The treatment group was then given purple sweet potato tuber extract with 3 doses, including 200mg/kg (P1), 400mg/kg (P2), and 800mg/kg (P3) for 2 weeks, and the food was returned to standard food.
Results: There was a significant increase in ABCA1 levels in P2 and P3 compared to negative controls (P <0.05), but the increase in ABCA1 in P3 was not different from positive controls.
Latar Belakang : Menjaga homeostasis kadar lemak tubuh merupakan hal yang penting. ABCA1 merupakan protein yang penting dalam fungsi efluks kolestrol yang dapat menjaga homeostasis profil lipid. Ubi ungu (Ipomoea batatas) merupakan tanaman Convolvulaceae yang memiliki berbagai fungsi biologis, salah satunya kandungan Antosianin yang diketahui dapat mencegah hiperlipidemia melalui sintesis ABCA1. Penelitian ini bertujuan untuk menguji efek ekstrak umbi ubi jalar ungu terhadap peningkatan kadar ABCA1
Metode : Desain penelitian post test only dengan kontrol grup menggunakan 50 ekor tikus wistar jantan yang dibagi menjadi 5 kelompok (n=10). Kelompok perlakuan negatif (P0) diberikan pakan standar sedangkan kelompok positif (P4), perlakuan 1(P1), perlakuan 2(P2) dan perlakuan 3(P3) diberikan diet hiperlipidemia selama 8 minggu. Kelompok perlakuan kemudian diberikan ekstrak umbi ubi jalar ungu dengan 3 dosis, antara lain 200mg/kg(P1), 400mg/kg(P2), 800mg/kg(P3) selama 2 minggu dan makanannya dikembalikan ke makanan standar.
Hasil : Terdapat peningkatan kadar ABCA1 yang signifikan pada P2 dan P3 dibandingkan dengan kontrol negatif (P<0,05) tetapi peningkatan ABCA1 pada P3 tidak berbeda dengan kontrol positif.
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How to Cite
Ardiana, I. K. R., Narayana, G. S., Pramartha, I. N. T., Pinatih, G. N. I., & Duarsa, D. P. (2023). Efek ekstrak umbi ubi jalar ungu (Ipomoea batatas) terhadap peningkatan ekspresi ABCA1 pada tikus model dislipidemia. Intisari Sains Medis, 14(2), 753–755. https://doi.org/10.15562/ism.v14i2.899
