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Peran Epigallocatechin-3-gallate (EGCG) dalam Menghambat Perkembangan Fibrosis Pleura, Ekspresi SCUBE3, dan Transforming Growth Factror-β (TGF-β) pada Pasien Empiema: sebuah tinjauan pustaka

  • Muhammad Riendra ,
  • Nur Indrawaty Lipoeto ,
  • Rauza Sukma Rita ,
  • Masrul Basyar ,


Empyema in the lungs can cause pulmonary fibrosis which can cause restrictions in the movement of the lung parenchyma. Epigallocatechin-3-gallate (EGCG) is the most active polyphenolic compound in gambier leaves (Uncaria gambir Roxb), which is known to inhibit the occurrence of pulmonary fibrosis due to empyema. This literature review discusses the role of EGCG in inhibiting the development of pleural fibrosis in empyema patients.

EGCG prevents bleomycin-induced increase in ROS formation, reverses the decrease in antioxidant status, and increases Nrf2 activity. EGCG also reduces inflammatory markers such as NF-κB, TNFα, IL-1β, and MPO activity levels and reduces histological signs of inflammation and lung injury. EGCG lowers hydroxyproline and glycoconjugates, products of collagen metabolism, reduces matrix-degrading lysosomal hydrolases and improves ultrastructural changes in the lungs. EGCG also exerts antifibrotic activity by suppressing the expression of TGF-β and the SCUBE3 gene.

The EGCG compound inhibits the development of pulmonary fibrosis in empyema through antioxidant and antifibrotic activities by suppressing SUBE3 and TGF-β gene expression.


Empiema pada paru dapat menyebabkan terjadinya fibrosis paru yang dapat menyebabkan restriksi pada pergerakan parenkim paru. Epigallocatechin-3-gallate (EGCG) adalah senyawa polifenol paling aktif dalam daun gambir (Uncaria gambir Roxb) yang diketahui dapat menghambat terjadinya fibrosis paru akibat empiema. Tinjauan pustaka ini membahas mengenai peran EGCG dalam menghambat perkembangan fibrosis pleura pada pasien empiema.

EGCG mencegah peningkatan pembentukan ROS yang diinduksi bleomisin, mengembalikan penurunan status antioksidan, dan meningkatkan aktivitas Nrf2. EGCG juga mengurangi penanda peradangan seperti tingkat aktivitas NF-κB, TNFα, IL-1β dan MPO serta mengurangi tanda-tanda histologis peradangan dan cedera paru-paru. EGCG menurunkan kadar hidroksiprolin dan glikokonjugat, produk metabolisme kolagen, mengurangi hidrolase lisosom yang menurunkan matriks, dan memperbaiki perubahan ultrastruktur di paru-paru. EGCG juga melakukan aktivitas antifibrotik dengan menekan ekspresi TGF-β dan gen SCUBE3.

Senyawa EGCG mampu menghambat perkembangan fibrosis paru pada empiema melalui aktivitas antioksidan dan antifibrotik dengan menekan ekspresi gen SUBE3 dan TGF-β.


  1. Bostock IC, Sheikh F, Millington TM, Finley DJ, Phillips JD. Contemporary outcomes of surgical management of complex thoracic infections., Journal of Thoracic Disease. 2018;10(9):5421–5427.
  2. Perhimpunan Dokter Paru Indonesia (PDPI). Panduan Umum Penyakit Paru dan Pernafasan. Bidang Jaminan Kesehatan Kesehatan dan Perumahsakitan - Perhimpunan Dokter Paru Indonesia. 2021.
  3. Bobbio A, Bouam S, Frenkiel J, Zarca K, Fournel L, Canny E, et al. Epidemiology and prognostic factors of pleural empyema, Thorax BMJ. 2021;76 (11):1117– 1123.
  4. Feller-Kopman, D, Light R. Pleural Disease., The New England Journal of Medicine United States. 2018;378 (8):740–751.
  5. Khalil H, Kanisicak O, Prasad V, Correll RN, Fu X, Schips T, et al. Fibroblast-specific TGF-β- Smad2/3 signaling underlies cardiac fibrosis., The Journal of Clinical Investigation. 2017;127(10):3770–3783.
  6. Huo Q, He X, Li Z, Yang F, He S, Shao L, Xie N, et al. SCUBE3 serves as an independent poor prognostic factor in breast cancer., Cancer Cell International. 2021;21(1):268.
  7. Lin YC, Sahoo BK, Gau SS, Yang RB. The biology of SCUBE. J Biomed Sci. 2023;30(1):1–45.
  8. Panji M, Behmard V, Zare Z, Malekpour M, Nejabligari H, Yavari S, et al. Suppressing effects of green tea extract and Epigallocatechin-3-gallate (EGCG) on TGF-β- induced Epithelial- to-mesenchymal transition via ROS/Smad signaling in human cervical cancer cells, Gene. patient-level data, Annals of Internal Medicine. 2021;135 (2):73–87.
  9. Sicard AA, Suarez NG, Cappadocia L, Annabi B. Functional targeting of the TGF-βR1 kinase domain and downstream signaling: A role for the galloyl moiety of green tea-derived catechins in ES-2 ovarian clear cell carcinoma, Journal of Nutritional Biochemistry Elsevier Inc. 2021;87(1):108518.
  10. Tabuchi M, Hayakawa S, Honda E, Ooshima K, Itoh T, Yoshida K, et al. Epigallocatechin-3- gallate suppresses transforming growth factor-beta signaling by interacting with the transforming growth factor-beta type II receptor. World J Exp Med. 2013;3(1):100–107.
  11. Tsai MJ, Chang WA, Liao SH, Chang KF, Sheu CC, Kuo PL. The effects of epigallocatechin gallate (EGCG) on pulmonary fibroblasts of idiopathic pulmonary fibrosis (Ipf)—a next-generation sequencing and bioinformatic approach. Int J Mol Sci. 2019; 20(8):1958.
  12. Batra H, Antony VB. Pleural mesothelial cells in pleural and lung diseases., Journal of Thoracic Disease. 2015;7(6):964–980.
  13. Herawati S, Kandarini Y, Mulyantari NK, Prabawa PY. Correlation of Neutrophil to Lymphocyte Ratio with Interleukin-10 in Diagnosis and Monitoring of Coronavirus Disease-19 Patients. Open Access Macedonian Journal of Medical Sciences. 2022;10(B):63-66.
  14. Cui H, Liu G. DOCK-t(w)o Pleural Fibrosis, American Journal of Respiratory Cell and Molecular Biology. 2022;66(2):117–119.
  15. Dituri F, Cossu C, Mancarella S, Giannelli G. The interactivity between TGFβ and BMP signaling in organogenesis, fibrosis, and cancer. Cells. 2019;8(10):1130.
  16. Pawlak JB, Blobe GC. TGF‐β superfamily co‐receptors in cancer. Developmental Dynamics. 2022;251(1):117–143.
  17. Tu CF, Tsao KC, Lee SJ, Yang RB. SCUBE3 (signal peptide- CUB-EGF domain-containing protein 3) modulates fibroblast growth factor signaling during fast muscle development. Journal of Biological Chemistry. 2014;289(27):18928–18942.
  18. Fiorelli A, Ricci S, Feola A, Mazzella A, D’Angelo L, Santini M, et al. Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in diagnosis of pleural effusion of malignant origin. Interact Cardiovasc Thorac Surg. 2016;22(4):411–418.
  19. Wu YT, Chen L, Tan ZB, Fan HJ, Xie LP, Zhang W, et al. Luteolin inhibits vascular smooth muscle cell proliferation and migration by inhibiting TGFBR1 signaling, Frontiers in Pharmacology. 2018;9(SEP):1–11.
  20. Yang F, Chen S, He S, Huo Q, Hu Y, Xie N. YB-1 interplays with ERα to regulate the stemness and differentiation of ER-positive breast cancer stem cells, Theranostics Ivyspring International Publisher. 2020;10(8):3816.
  21. Reygaert WC. Green tea catechins: Their use in treating and preventing infectious diseases. Biomed Res Int. 2018;1(1):1-9.
  22. Mokra D, Adamcakova J, Mokry J. Green tea polyphenol (-)- Epigallocatechin-3-Gallate (egcg): a time for a new player in the treatment of respiratory diseases? Antioxidants. 2022;11(8):1566.
  23. Li T, Zhao N, Lu J, Zhu Q, Liu X, Hao F, et al. Epigallocatechin gallate (EGCG) suppresses epithelial-Mesenchymal transition (EMT) and invasion in anaplastic thyroid carcinoma cells through blocking of TGF-β1/Smad signaling pathways, Bioengineered Taylor & Francis. 2019;10(1):282.

How to Cite

Riendra, M., Lipoeto, N. I., Rita, R. S., & Basyar, M. (2024). Peran Epigallocatechin-3-gallate (EGCG) dalam Menghambat Perkembangan Fibrosis Pleura, Ekspresi SCUBE3, dan Transforming Growth Factror-β (TGF-β) pada Pasien Empiema: sebuah tinjauan pustaka. Intisari Sains Medis, 15(1), 495–500.




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Muhammad Riendra
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Nur Indrawaty Lipoeto
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Rauza Sukma Rita
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Masrul Basyar
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