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Rokok elektrik dan tuberkulosis paru: sebuah tinjauan pustaka

  • I Desak Putu Agung Krisdanti ,
  • Adelia Ghosali ,


Background: Currently, the use of e-cigarettes has become a concern for the scientific community to research the health effects of e-cigarettes, other unknown components of e-cigarettes, the lack of international policy regarding quality control of e-cigarette production, and the impact on non-smokers. e-cigarette users, or people who already smoke and become dual users (tobacco cigarettes and e-cigarettes). This literature review attempts to discuss the relationship between e-cigarettes and the incidence of pulmonary tuberculosis based on theoretical studies.

Methods: This literature review involves relevant literature on e-cigarettes and pulmonary tuberculosis. Different data sources or manual literature search methods were used to search for articles related to the literature topic.

Results: Nicotine in e-cigarettes can cause airway inflammation and increase the risk of susceptibility to bacterial infections, one of which is MTB infection. According to several studies, e-cigarette e-vapor interferes with the phagocytic function of THP-1 macrophages against MTB and is a promoter of pro-inflammatory responses. Cigarette smoke also affects phagocytic function and reduces effector cytokine responses (TNF-α, IL-1β, and IL-8).

Conclusion: E-cigarette smoke can affect phagocytic function and reduce effector cytokine responses (TNF-α, IL-1β, and IL-8), thereby increasing the risk of susceptibility to tuberculosis bacterial infection.


Latar Belakang: Dewasa ini penggunaan rokok elektrik telah menjadi perhatian oleh komunitas ilmiah untuk meneliti efek kesehatan dari rokok elektrik, komponen rokok elektrik lainnya yang belum diketahui pasti, rendahnya kebijakan internasional terkait kontrol kualitas dari produksi rokok elektrik, dan dampak pada orang yang bukan perokok menjadi pengguna rokok elektrik, atau pada orang yang sudah merokok menjadi dual-users (rokok tembakau dan rokok elektrik). Tinjauan pustaka ini mencoba membahas hubungan rokok elektrik dengan kejadian tuberkulosis paru berdasarkan kajian teoritis.

Metode: Tinjauan pustaka ini melibatkan literatur yang relevan tentang rokok elektrik dan tuberculosis paru. Sumber data yang berbeda atau metode pencarian literatur manual digunakan untuk mencari artikel yang berkaitan dengan topik literatur.

Hasil: Nikotin pada rokok elektrik dapat menyebabkan inflamasi saluran napas dan meningkatkan risiko kerentanan terhadap infeksi bakteri, salah satunya infeksi MTB. Menurut beberapa penelitian, e-vapor rokok elektrik mengganggu fungsi fagositik makrofag THP-1 terhadap MTB dan sebagai promotor respon proinflamasi. Asap rokok juga mempengaruhi fungsi fagositik dan mengurangi respons sitokin efektor (TNF-α, IL-1β, dan IL-8).

Simpulan: Asap rokok elektrik dapat mempengaruhi fungsi fagositik dan mengurangi respons sitokin efektor (TNF-α, IL-1β, dan IL-8) sehingga meningkatkan risiko kerentanan terhadap infeksi bakteri tuberkulosis.


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How to Cite

Krisdanti, I. D. P. A., & Ghosali, A. (2024). Rokok elektrik dan tuberkulosis paru: sebuah tinjauan pustaka. Intisari Sains Medis, 15(1), 201–209.




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Adelia Ghosali
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