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Osteolytic lesion in primary intracranial meningioma: A case report


Background: Hyperostosis of the skull is one of the characteristics of intracranial meningioma. In contrast, osteolytic lesions are very rarely discovered in meningioma. This study presented a rare instance of intracranial meningioma accompanied by significant osteolytic lesions.

Case presentation: A 70-year-old male patient presented with a chief complaint of a left-sided scalp lump which developed progressively within two years. Seizures and right-sided weakness have been reported. A mass of approximately 8 cm in diameter with a smooth surface was noted during a physical examination. The brain magnetic resonance imaging revealed an ± 10 x 9.6 x 8.6 cm lobulated homogeneous mass on the left temporoparietal region and heterogeneously enhanced after intravenous contrast injection. A localized osteolytic lesion was detected extending from the left temporal region to the left parietal region. A craniectomy was performed to obtain the pathological diagnosis and for complete removal of the mass. Histopathological evaluation revealed the presence of an atypical meningioma.

Conclusion: Bone destruction by meningioma may occur because of either neoplastic infiltration or pressure erosion.


  1. Ogasawara C, Philbrick BD, Adamson DC. Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment, and Future Directions. Biomedicines. 2021;9(3):319.
  2. Da Broi M, Borrelli P, Meling TR. Predictors of Survival in Atypical Meningiomas. Cancers (Basel). 2021;13(8):1970.
  3. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO Classification of Tumors of the Central Nervous System: A Summary. Neuro Oncol. 2021;23(8):1231-1251.
  4. Widodo D, Ihwan A, Arungpadang MP. Evaluasi kasus meningioma di Rumah Sakit Wahidin Sudirohusodo Makassar tahun 2012 – 2018. Intisari Sains Medis. 2020;11(3):1345-1348.
  5. Du L, Tang Y, Zhao H, Wang X. Surgical treatment of elderly patients with primary osteolytic atypical meningioma: a case report and review of the literature. Chinese Neurosurgical Journal. 2017;3(04):247-251.
  6. Moon H-S., Jung S, Jung T-Y, Cao V-T, Moon K-S, Kim I-Y. Possible Role of Matrix Metalloproteinase in Osteolytic Intracranial Meningiomas. J Korean Neurosurg Soc. 2010;47(1):11-16.
  7. Holleczek B, Zampella D, Urbschat S, Sahm F, von Deimling A, Oertel J, Ketter R. Incidence, mortality and outcome of meningiomas: A population-based study from Germany. Cancer Epidemiol. 2019;62:101562.
  8. Huang RY, Bi WL, Griffith B, Kaufmann TJ, la Fougère C, Schmidt NO, et al. Imaging and diagnostic advances for intracranial meningiomas. Neuro Oncol. 2019;21(Suppl 1):i44-i61.
  9. Wang N, Osswald M. Meningiomas: Overview and New Directions in Therapy. Semin Neurol. 2018;38(1):112-120).
  10. Goldbrunner R, Minniti G, Preusser M, Jenkinson MD, Sallabanda K, Houdart E, et al. EANO guidelines for the diagnosis and treatment of meningiomas. Lancet Oncol. 2016;17(9):e383-e391.
  11. Champeaux C, Houston D, Dunn L. Atypical meningioma. A study on recurrence and disease-specific survival. Neurochirurgie. 2017;63(4):273-281.
  12. Euskirchen P, Peyre M. Management of meningioma. Presse Med. 2018;47(11-12 Pt 2):e245-e252.
  13. Huntoon K, Toland AMS, Dahiya S. Meningioma: A Review of Clinicopathological and Molecular Aspects. Front Oncol. 2020;10:579599.
  14. Shaikh N, Dixit K, Raizer J. Recent advances in managing/understanding meningioma. F1000Res. 2018;7:F1000 Faculty Rev-490.
  15. Vranic A, Popovic M, Cör A, Prestor B, Pizem J. Mitotic count, brain invasion, and location are independent predictors of recurrence-free survival in primary atypical and malignant meningiomas: a study of 86 patients. Neurosurgery. 2010;67(4):1124-1132.
  16. Olmsted WW, McGee TP. Prognosis in meningioma through evaluation of skull bone patterns. Radiology. 1977;123(2):375-377.

How to Cite

Wirotama, A. D., Steven Tandean, & D’Prinzessin, C. A. . (2024). Osteolytic lesion in primary intracranial meningioma: A case report. Intisari Sains Medis, 15(1), 22–24.




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Androcles Dwi Wirotama
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Steven Tandean
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Celine Augla D’Prinzessin
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