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Preventing mother-to-child transmission of human immunodeficiency virus (HIV), syphilis and hepatitis B: a secondary hospital approach in North Bali, Indonesia

  • Aditya Prabawa ,
  • Putu Sudarsana ,
  • Komang Hendra Setiawan ,


Abstract

Background Mother-to-child transmission (MTCT) of human immune virus (HIV), syphilis, and hepatitis B can lead to significant health burdens and even mortality in children. This study aimed to evaluate the effectiveness of triple elimination of MTCT in a secondary hospital in Buleleng, North Bali

Method: This study conducted a retrospective review of 345 pregnancy case in Buleleng General Hospital from January to December 2022

Result: In this study, 98.5% of the 345 pregnant women seeking antenatal care were tested for HIV, syphilis, and hepatitis B. Among the tested patients, 100%, 99.7%, and 98.8% were tested for HIV and hepatitis B, HIV and syphilis, and syphilis and hepatitis B, respectively. The prevalence of HIV, syphilis, and hepatitis B was 1.4%, 2.1%, and 4.3 %, respectively. Antiretroviral therapy was administered to 80 % of HIV-positive patients, and 71.4 % of syphilis patients received benzathine penicillin G. Only 6.6% of hepatitis B patients received hepatitis B virus deoxyribonucleic acid (HBV DNA) & hepatitis B  envelope antigen (HBeAg) examination followed by Lamivudine administration.

Conclusion: Early detection of HIV, syphilis, and hepatitis B in pregnant women is important for preventing MTCT. Coverage of triple elimination screening is in accordance with WHO targets, but further management of hepatitis B needs to be improved

Keywords: hepatitis B HIV mother-to-child transmission syphilis triple elimination

References

  1. Mann JM. The World Health Organization's global strategy for the prevention and control of AIDS. West J Med. 1987;147(6):732-4.
  2. Korenromp EL, Rowley J, Alonso M, Mello MB, Wijesooriya NS, Mahiané SG, et al. Global burden of maternal and congenital syphilis and associated adverse birth outcomes-Estimates for 2016 and progress since 2012. PLoS One. 2019;14(2):e0211720–e0211720. Available from: https://pubmed.ncbi.nlm.nih.gov/30811406
  3. Najmah, Andajani S, Davies SG. Perceptions of and barriers to HIV testing of women in Indonesia. Sex Reprod Health Matters. 2020 Dec;28(2):1848003. doi: 10.1080/26410397.2020.1848003. PMID: 33308109; PMCID: PMC7888028.4.
  4. Lumbantoruan C, Kelaher M, Kermode M. Pregnant women’s retention and associated health facility characteristics in the prevention of mother-to-child HIV transmission in Indonesia: cross-sectional study. BMJ Open. 2020;10:e034418. Available from: doi: 10.1136/bmjopen-2019-034418
  5. Pai NP, Tulsky JP, Cohan D, Colford JM, Reingold AL. Rapid point-of-care HIV testing in pregnant women: a systematic review and meta-analysis. Trop Med & Int Heal. 2007;12(2):162–73. Available from: http://dx.doi.org/10.1111/j.1365-3156.2006.01812.x
  6. Gliddon HD, Peeling RW, Kamb ML, Toskin I, Wi TE, Taylor MM. A systematic review and meta-analysis of studies evaluating the performance and operational characteristics of dual point-of-care tests for HIV and syphilis. Sex Transm Infect. 2017/07/26. 2017;93(S4):S3–15. Available from: https://pubmed.ncbi.nlm.nih.gov/28747410
  7. Boucheron P, Lu Y, Yoshida K, Zhao T, Funk AL, Lunel-Fabiani F, et al. Accuracy of HBeAg to identify pregnant women at risk of transmitting hepatitis B virus to their neonates: a systematic review and meta-analysis. Lancet Infect Dis. 2021;21(1):85–96. Available from: http://dx.doi.org/10.1016/s1473-3099(20)30593-4
  8. Fan L, Owusu‐Edusei K, Schillie SF, Murphy T V. Cost‐effectiveness of active‐passive prophylaxis and antiviral prophylaxis during pregnancy to prevent perinatal hepatitis B virus infection. Hepatology. 2015;63(5):1471–80. Available from: http://dx.doi.org/10.1002/hep.28310
  9. Funk AL, Lu Y, Yoshida K, Zhao T, Boucheron P, van Holten J, et al. Efficacy and safety of antiviral prophylaxis during pregnancy to prevent mother-to-child transmission of hepatitis B virus: a systematic review and meta-analysis. Lancet Infect Dis. 2021;21(1):70–84. Available from: http://dx.doi.org/10.1016/s1473-3099(20)30586-7
  10. Mashamba-Thompson TP, Morgan RL, Sartorius B, Dennis B, Drain PK, Thabane L. Effect of Point-of-Care Diagnostics on Maternal Outcomes in Human Immunodeficiency Virus–Infected Women. Point Care J Near-Patient Test & Technol. 2017;16(2):67–77. Available from: http://dx.doi.org/10.1097/poc.0000000000000135
  11. Morshed MG, Singh AE. Recent trends in the serologic diagnosis of syphilis. Clin Vaccine Immunol. 2014/11/26. 2015;22(2):137–47. Available from: https://pubmed.ncbi.nlm.nih.gov/25428245
  12. Ebenezer ED, Benjamin SJ, Sahni RD, Prakash JAJ, Chelliah H, Mathews JE. A retrospective study of the prevalence and outcomes of syphilis in pregnancy in a 5-year period. Int J Gynecol & Obstet. 2017;140(1):42–6. Available from: http://dx.doi.org/10.1002/ijgo.12336
  13. Negara IKS, Anantasika AAN, Putra A, Wiradnyana AAP, Tunas IK. Characteristics of Pregnant Women with HIV Infection Following Prevention of Mother to Child Transmission of HIV (PMTCT) Program in Sanglah General Hospital 2005-2014. Bali Med J. 2016;5(1):165. Available from: http://dx.doi.org/10.15562/bmj.v5i1.291

How to Cite

Prabawa, A., Putu Sudarsana, & Setiawan, K. H. . (2023). Preventing mother-to-child transmission of human immunodeficiency virus (HIV), syphilis and hepatitis B: a secondary hospital approach in North Bali, Indonesia. Intisari Sains Medis, 14(2), 641–644. https://doi.org/10.15562/ism.v14i2.1752
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Aditya Prabawa
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Putu Sudarsana
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Komang Hendra Setiawan
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