Skip to main content Skip to main navigation menu Skip to site footer

Hubungan subtipe molekuler kanker payudara dengan grading histopatologi di RSUD M Yunus Bengkulu

  • Galuh Setyorini ,
  • Lia Sasmithae ,
  • Panji Irani Fianza ,
  • Dian Kurnia ,


Abstract

Introduction. Breast cancer is a disease with complex and heterogeneous condition which can be assessed from its morphology, molecular subtypes, and patient response to treatment. Treatment is individualized based on predictive and prognostic factors. Based on this, molecular examination is very important and the Muhammad Yunus Bengkulu Hospital opened cancer patient services and continues to improve its services, especially for breast cancer. It has been recorded since mid-2021 that were 77 patients who underwent  immunohistochemical examinations independently. The purpose of this study was to determine the distribution of various molecular subtypes of breast cancer at M Yunus Hospital Bengkulu and their relationship with histopathological grading in breast cancer patients.

Method. A cross-sectional study was conducted on breast cancer patients who went  to the Surgical Oncology Polyclinic at M Yunus Bengkulu Hospital. In this study, we used medical record data in the form of laboratory results as research subjects, which were then analyzed  using SPSS 25 for windows. The relationship between variables is stated to  significant if the p-value <0.05.

Results. From 77 breast cancer patients whose molecular subtypes were examined, the average age was 50 (standard deviation of 12) years. Most of the histopathological grades were grade 3 (41.60%), then grade 2 (23.40%), at least grade 1 (5.20%), and could not be determined quite a lot, namely 29.9%. ER status was mostly positive (67.50%), then PR status was more positive (53.20%), HER2 was mostly negative (61.00%), and triple-negative was 13.00%. For Ki67, mostly >20% (75.30%). According to the findings of statistical analyses using the Chi-Square test, p>0.05, indicates that there is no correlation between the histopathological grade and the molecular subtype of breast cancer patients (p=0.199).

Conclusion. Histopathological grading and molecular subtype do not significantly correlate.

 

Pendahuluan. Kanker pada payudara merupakan suatu penyakit dengan kondisi yang komplek dan heterogen yang dapat dinilai dari bentuk morfologi, subtipe molekuler nya, respon pasien terhadap pengobatan karena pengobatan bersifat individual yang berdasarkan faktor prediktif dan prognostik. Berdasarkan hal tersebut maka pemeriksaan molekuler sangatlah penting, dan di Rumah Sakit Muhammad Yunus Bengkulu membuka layanan pasien kanker dan terus  meningkatkan pelayanannya terutama pada kanker payudara dan sudah tercatat sejak pertengahan 2021 terdapat 77 pasien yang dilakukan pemeriksaan immunohistokimia secara mandiri. Tujuan pada penelitian ini adalah untuk mengetahui distribusi pada berbagai subtipe molekuler kanker payudara di RSUD M Yunus Bengkulu dan  hubungan nya dengan grading histopatologinya pada penderita kanker payudara.

Metode. Studi potong lintang dilakukan pada penderita kanker payudara yang berobat rutin ke Poliklinik Bedah Onkologi di RSUD M Yunus Bengkulu. Pada penelitian ini menggunakan data rekam medik yang berupa hasil laboratorium sebagai subjek penelitiannya yang selanjutnya di analisis menggunakan SPSS 25 for windows. Hubungan antar variabel dinyatakan bermakna apabila nilai p<0,05.

Hasil. Dari total 77 subjek pasien kanker payudara yang di periksa subtipe molekulernya didapatkan rerata usia 50 (simpang baku 12) tahun. Didapatkan grade histopatologis paling banyak grade 3 (41,60%), kemudian grade 2 (23,40%), yang paling sedikit grade 1 (5,20%), dan tidak dapat ditentukan cukup banyak yaitu 29,90%. Status ER sebagian besar positif (67,50%), kemudian status PR lebih banyak positif (53,20%), sedangkan HER2 sebagian besar negatif (61,00%), Triple negatif ada sebesar 13,00%. Ki67 sebagian besar >20% (75,30%). Dari hasil uji statistik dengan Uji Chi-Square p>0.05 yang artinya subtipe molekuler pada pasien kanker payudara tidak memiliki hubungan dengan grading histopatologinya (p=0.199).

Simpulan. Tidak ada hubungan bermakna antara subtipe molekuler dengan grading histopatologis nya.

Keywords: immunohistokimia grading histopatologi Kanker payudara

References

  1. Parmar V, Nair NS, Thakkar P, Chitkara G. Molecular Biology in the Breast Clinics-Current status and future perspectives. Indian journal of surgical oncology. 2019/08/10. 2021;12(Suppl 1):7–20. Available from: https://pubmed.ncbi.nlm.nih.gov/33994723
  2. Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, et al. Current and future burden of breast cancer: Global statistics for 2020 and 2040. Breast (Edinburgh, Scotland). 2022/09/02. 2022;66:15–23. Available from: https://pubmed.ncbi.nlm.nih.gov/36084384
  3. Kementrian Kesehatan Republik Indonesia. Laporan Nasional Riset Kesehatan Dasar [Internet]. Badan Penelitian dan Pengembangan Kesehatan. 2018. p. 198. Available from: http://labdata.litbang.kemkes.go.id/images/download/laporan/RKD/2018/Laporan_Nasional_RKD2018_FINAL.pdf
  4. Indonesia KKR. Peraturan Menteri Kesehatan tentang Penanggulangan Kanker Payudara Dan Kanker Leher Rahim [Internet]. 2015. Available from: https://peraturan.bpk.go.id/Home/Details/116060/permenkes-no-34-tahun-2015
  5. Indonesia KKR. Kanker Payudara Paling Banyak di Indonesia, Kemenkes Targetkan Pemerataan Layanan Kesehatan [Internet]. 2022. Available from: https://www.kemkes.go.id/article/view/22020400002/kanker-payudara-paling-banyak-di-indonesia-kemenkes-targetkan-pemerataan-layanan-kesehatan.html
  6. Horvath E. Molecular subtypes of breast cancer-what breast imaging radiologists need to know. Revista Chilena de Radiologia. 2021;27(1):17–26.
  7. Dai X, Li T, Bai Z, Yang Y, Liu X, Zhan J, et al. Breast cancer intrinsic subtype classification, clinical use and future trends. American journal of cancer research. 2015;5(10):2929–43.
  8. Zaha DC. Significance of immunohistochemistry in breast cancer. World journal of clinical oncology. 2014;5(3):382–92. Available from: https://pubmed.ncbi.nlm.nih.gov/25114853
  9. Unger-Saldaña K. Challenges to the early diagnosis and treatment of breast cancer in developing countries. World journal of clinical oncology. 2014;5(3):465–77. Available from: https://pubmed.ncbi.nlm.nih.gov/25114860
  10. Angela D, Ardiansyah D, Agung Suprabawati DG. Hubungan intensitas nyeri dengan kualitas hidup pasien kanker payudara yang menjalani kemoterapi di PPLK RSUD Dr. Soetomo. Intisari Sains Medis. 2022;13(1):109–16.
  11. Łukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, Stanisławek A. Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review. Cancers. 2021;13(17):4287. Available from: https://pubmed.ncbi.nlm.nih.gov/34503097
  12. Tariq R, Huma S, Butt M, Amin F. Risk factors and prevalence of breast cancer - A review. Journal of the Pakistan Medical Association. 2013;63:1075–8.
  13. Pasaribu ET, Issakh B, Maritska Z. Trend kanker payudara di Semarang: Analisis tipe histologi dan molekuler. Jurnal Kedokteran dan Kesehatan Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya. 2018;5(3):108–13. Available from: http://dx.doi.org/10.32539/jkk.v5i3.6312
  14. Lumintang L, Susanto A, Gadri R, Djatmiko A. Profil Pasien Kanker Payudara di Rumah Sakit Onkologi Surabaya. Indonesian Journal of Cancer. 2015;9(3):105–10.
  15. Nanto SS, Muhartono, Wulan AJ. Peran Estrogen Receptor ( ER ), Progesteron Receptor ( PR ), dan Human Epidermal Growth Factor Receptor 2 ( HER-2 ) untuk Memprediksi Stadium Klinis Kanker Payudara. J Agromed Unila. 2017;4(2):257–9.
  16. Fulga V, Rudico L, Balica AR, Cimpean AM, Saptefrati L, Raica M. Invasive ductal carcinoma of no special type and its corresponding lymph node metastasis: do they have the same immunophenotypic profile? Polish Journal of Pathology. 2015;1:30–7. Available from: https://peraturan.bpk.go.id/Home/Details/116060/permenkes-no-34-tahun-2015
  17. Nascimento RG do, Otoni KM. Histological and molecular classification of breast cancer: what do we know? Mastology. 2020;30. Available from: http://dx.doi.org/10.29289/25945394202020200024
  18. Wang Y, Acs B, Robertson S, Liu B, Solorzano L, Wählby C, et al. Improved breast cancer histological grading using deep learning. Annals of Oncology. 2022;33(1):89–98. Available from: http://dx.doi.org/10.1016/j.annonc.2021.09.007
  19. Rustamadji P, Marisca S. Karakteristik Histopatologik dan Imunofenotipik Kanker Payudara di Rumah Sakit Cipto Mangunkusumo Jakarta, Indonesia. Medicinus. 2018;6(3). Available from: http://dx.doi.org/10.19166/med.v6i3.1147
  20. Syukri NA, Fidiawati WA, Tripriadi ES. Profil Pemeriksaan Indeks Proliferatif Ki-67 pada Penderita Kanker Payudara di RSUD Arifin Achmad Tahun 2010-201. Jurnal Online Mahasiswa Fakultas Kedokteran Universitas Riau. 2016;3(1):1–13.
  21. Yersal O, Barutca S. Biological subtypes of breast cancer: Prognostic and therapeutic implications. World journal of clinical oncology. 2014;5(3):412–24. Available from: https://pubmed.ncbi.nlm.nih.gov/25114856
  22. Furrer D, Paquet C, Jacob S, Diorio C. The Human Epidermal Growth Factor Receptor 2 (HER2) as a Prognostic and Predictive Biomarker: Molecular Insights into HER2 Activation and Diagnostic Implications [Internet]. Cancer Prognosis. IntechOpen; 2018. Available from: http://dx.doi.org/10.5772/intechopen.78271

How to Cite

Setyorini, G. ., Sasmithae, L. ., Fianza, P. I. ., & Kurnia, D. . (2023). Hubungan subtipe molekuler kanker payudara dengan grading histopatologi di RSUD M Yunus Bengkulu. Intisari Sains Medis, 14(2), 519–524. https://doi.org/10.15562/ism.v14i2.1738
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver
Download Citation
Endnote/Zotero/Mendeley (RIS) BibTeX

HTML
0

Total
0

Share

Search Panel

Galuh Setyorini
Google Scholar
Pubmed
ISM Journal

Lia Sasmithae
Google Scholar
Pubmed
ISM Journal

Panji Irani Fianza
Google Scholar
Pubmed
ISM Journal

Dian Kurnia
Google Scholar
Pubmed
ISM Journal