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Nanoenkapsulasi senyawa bioaktif daun salam (Syzygium polyanthum) menggunakan surfaktan tween 80 di dalam ruang berbentuk tabung berdiameter 500 μm



Abstract

Background: The bioactive compounds found in bay leaves have an abundance of potential to be used in the future, particularly as pharmaceutical ingredients as they consist of several beneficial characteristics, such the ability to reduce cholesterol and act as antioxidants, anti-inflammatory, and antibacterial. These bioactive compounds also have characteristics that make it very difficult for them to dissolve in water, evaporate easily, and decay easily, leading to numerous difficulties for their utilization. This problem has been solved using the nanoencapsulation method.

Objective: This study aimed to nanoencapsulate bioactive compounds in bay leaves using a surfactant in a 500 μm diameter tube.

Method: Tween 80 surfactant was used to perform nanoencapsulation in a tubular chamber with a diameter of 500 μm. A very small and constant amount of the liquid precursor mixture can be used in a tubular chamber with a very small diameter to produce nanoparticles with a tiny size. Precursor mixing occurs very quickly because of the immense mass movement in the tube.

Results: The average diameter of nanoparticles produced through nanoencapsulation ranges from 16.6 nm to 20.3 nm. There were four distinct mass concentrations of the bioactive compounds found in bay leaves used: 8 mg, 10 mg, 12 mg, and 14 mg. It was discovered that the average diameter of the produced nanoparticles and their polydispersity index rose as the mass of the utilized bioactive compounds concentrate increased.

Conclusions: According to the results of this study, bay leaf bioactive compound nanoparticles were successfully encapsulated in nanometers utilizing a 500 μm diameter tube-shaped chamber. The resulting nanoparticles have a single distribution and average sizes that are relatively small.

 

Latar Belakang: Senyawa bioaktif daun salam memiliki potensi yang sangat besar untuk dikembangkan ke depan terutama sebagai bahan obat-obatan karena memiliki sifat-sifat yang sangat berguna, seperti: dapat menurunkan kolesterol, bersifat antioksidan, antiinflamasi, dan antibakteri. Namun senyawa bioaktif ini juga memiliki sifat yang sangat sulit larut di dalam air, mudah menguap dan mudah terdegradasi sehingga pemanfaatannya mengalami banyak hambatan. Untuk mengatasi hal tersebut pendekatan nanoenkapsulasi dilakukan.

Tujuan: Penelitian ini bertujuan untuk menanoenkapsulasi senyawa bioaktif daun salam menggunakan suatu surfaktan di dalam ruang berbentuk tabung berdiameter 500 μm.

Metode: Nanoenkapsulasi dilakukan di dalam ruang berbentuk tabung berdiameter 500 μm menggunakan surfaktan tween 80. Di dalam ruang berbentuk tabung dan berdiameter sangat kecil, volume cairan campuran prekursor yang digunakan dapat diatur sangat kecil dan teratur sehingga nanopartikel yang diperoleh dapat berukuran sangat kecil. Proses pencampuran prekursornya sangat cepat karena transport massa di dalam tabung sangat tinggi.  

Hasil: Nanopartikel yang dihasilkan dari nanoenkapsulasi memiliki diameter rata-rata dari 16,6 nm – 20,3 nm. Empat ragam massa konsentrat senyawa bioaktif daun salam digunakan, yaitu 8 mg, 10 mg, 12 mg, dan 14 mg. Diperoleh bahwa ketika massa konsentrat senyawa bioaktif yang digunakan ditambah, diameter rata-rata nanopartikel yang dihasilkan dan indeks polidispersitasnya bertambah.

Simpulan: Nanopartikel senyawa bioaktif daun salam telah berhasil dienkapsulasi berukuran nanometer dengan menggunakan ruang berbentuk tabung berdiameter 500 μm. Ukuran diameter rata-rata nanopartikel yang dihasilkan pun sangat kecil dan berdistribusi tunggal.

Keywords: Nanoenkapsulasi senyawa bioaktif daun salam surfaktan tween 80 ruang berbentuk tabung

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How to Cite

Waruwu , A. S. D., & Saragih, H. (2023). Nanoenkapsulasi senyawa bioaktif daun salam (Syzygium polyanthum) menggunakan surfaktan tween 80 di dalam ruang berbentuk tabung berdiameter 500 μm. Intisari Sains Medis, 14(2), 456–465. https://doi.org/10.15562/ism.v14i2.1704
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Angel Sri Diendra Waruwu
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ISM Journal

Horasdia Saragih
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ISM Journal